Zyprexa |
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Zyprexa helps manage symptoms of schizophrenia, the manic phase of manic-depression, and other psychotic disorders. It is thought to work by opposing the action of serotonin and dopamine, two of the brain's major chemical messengers. The drug is available as Zyprexa tablets and Zyprexa Zydis, which dissolves rapidly with or without liquid. Schizophrenia drug class.
ziprexa, zyprexia, xyprexa, antipsychotic drugs, olanzapine effects, risk schizophrenia.
Zyprexa generic (generic - what is it?)
| Dosage |
Packing |
Price |
Add to basket |
| 2.5 mg |
100 tab |
USD 49.00 |
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| 5 mg |
100 tab |
USD 57.00 |
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| 7.5 mg |
100 tab |
USD 62.00 |
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| 10 mg |
100 tab |
USD 72.00 |
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Zyprexa: Medications and Prescriptions
Generic name: Olanzapine
Product Brand Name: Zyprexa
Zyprexa description
Why is this drug prescribed?
Zyprexa helps manage symptoms of schizophrenia, the manic phase of manic-depression, and other psychotic disorders. It is thought to work by opposing the action of serotonin and dopamine, two of the brain's major chemical messengers. The drug is available as Zyprexia tablets and Zyprexa Zydis, which dissolves rapidly with or without liquid.
Most important fact about this drug
At the start of Zyprexa therapy, the drug can cause extreme low blood pressure, increased heart rate, dizziness, and, in rare cases, a tendency to faint when first standing up. These problems are more likely if you are dehydrated, have heart disease, or take blood pressure medicine. To avoid such problems, your doctor may start with a low dose of Zyprexia and increase the dosage gradually.
How should you take this medication?
Zyprexia should be taken once a day with or without food. To use Zyprexia Zydis, open the sachet, peel back the foil on the blister pack, remove the tablet, and place the entire tablet in the mouth. Do not push the tablet through the foil. The medication can be taken with or without water; the saliva in your mouth will cause the tablet to dissolve.
--If you miss a dose... Take it as soon as you remember. If it is almost time for your next dose, skip the one you missed and go back to your regular schedule. Do not take 2 doses at once.
Storage
Store at room temperature away from light and moisture.
What side effects may occur?
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zyprexa.
· More common side effects may include:
Abdominal pain, abnormal gait, accidental injury, agitation, anxiety, back pain, behavior problems, blood in urine, blurred vision, chest pain, constipation, cough, dehydration, dizziness, drowsiness, dry mouth, extreme low blood pressure, eye problems, feeling of well-being, fever, headache, high blood pressure, hostility, increased appetite, increased cough, indigestion, inflammation of the nasal passages and throat, insomnia, joint pain, movement disorders, muscle rigidity, nausea, nervousness, pain in arms and legs, rapid heartbeat, restlessness, tension, tremor, weakness, weight gain
· Less common side effects may include:
Abnormal dreams, decreased sex drive, dental pain, diabetes, difficulty breathing, emotional instability, eye infection, increased salivation, intentional injury, involuntary movement, joint stiffness, low blood pressure, menstrual irregularities, nasal stuffiness, sleepiness, sore throat, suicide attempts, sweating, swelling of arms and legs, thirst, twitching, urinary problems, vaginal infection, vomiting
· Rare side effects may include:
Abnormal ejaculation, black bowel movements, bleeding, blood clots, bone pain, breast growth in males, breast pain, burping, chills, congestive heart failure, difficulty swallowing, dry eyes, dry skin, ear pain, change in taste sensation, enlarged abdomen, fever, gas, stomach upset, hair loss, hangover feeling, heart attack, inability to control bowel movements, migraine, mouth sores, neck pain, neck rigidity, osteoporosis, pallor, rash, rectal bleeding, rheumatoid arthritis, ringing in the ears, sensitivity to light, stroke, sudden death, swelling of face, swollen gums, yeast infection
Why should this drug not be prescribed?
If Zyprexa gives you an allergic reaction, you cannot take the drug.
Special warnings about this medication
Zyprexa sometimes causes drowsiness and can impair your judgment, thinking, and motor skills. Use caution while driving and don't operate dangerous machinery until you know how the drug affects you. Medicines such as Zyprexa can interfere with regulation of the body's temperature. Do not get overheated or become dehydrated while taking Zyprexa. Avoid extreme heat and drink plenty of fluids. Use Zyprexa with caution if you have any of the following conditions: Alzheimer's disease, Parkinson's disease, trouble swallowing, narrow angle glaucoma (high pressure in the eye), an enlarged prostate, heart irregularities, heart disease, heart failure, liver disease, or a history of heart attack, seizures, or intestinal blockage. Drugs such as Zyprexa sometimes cause a condition called Neuroleptic Malignant Syndrome. Symptoms include high fever, muscle rigidity, irregular pulse or blood pressure, rapid heartbeat, excessive perspiration, and changes in heart rhythm. If these symptoms appear, your doctor will have you stop taking Zyprexa while the condition is under treatment. There is also a risk of developing tardive dyskinesia, a condition marked by slow, rhythmical, involuntary movements. This problem is more likely to surface in older adults, especially elderly women. When it does, use of Zyprexa is usually stopped. If you have a child with phenylketonuria (the inability to process phenylalanine, a condition that quickly leads to mental retardation) you should be aware that Zyprexa contains this substance.
Possible food and drug interactions when taking this medication
Avoid alcohol while taking Zyprexia. The combination can cause a sudden drop in blood pressure.
If Zyprexa is taken with certain other drugs, the effects of either can be increased, decreased, or altered. Ask your doctor before taking any prescription or over-the-counter drugs. It is especially important to check before combining Zyprexa with the following: Blood pressure medications
Carbamazepine (Tegretol)
Diazepam (Valium)
Drugs that boost the effect of dopamine, such as the Parkinson's medications Mirapex, Parlodel, Permax, and Requip
Fluvoxamine (Luvox)
Levodopa (Larodopa)
Omeprazole (Prilosec)
Rifampin (Rifadin, Rimactane)
Special information if you are pregnant or breastfeeding
If you are pregnant or plan to become pregnant, inform your doctor immediately. Zyprexa should be used during pregnancy only if absolutely necessary. The drug may appear in breast milk; do not breastfeed while on Zyprexa therapy.
Recommended dosage
ADULTS:
Schizophrenia (Schizophrenia drug)
The usual starting dose is 5 to 10 milligrams once a day. If you start at the lower dose, after a few days the doctor will increase it to 10. After that, the dosage will be increased no more than once a week, 5 milligrams at a time, up to a maximum of 20 milligrams a day. Those most likely to start at 5 milligrams are the debilitated, people prone to low blood pressure, and nonsmoking women over 65 (because they tend to have a slow metabolism).
Manic Episodes in Manic-Depression
The usual starting dose is 10 to 15 milligrams once a day. The drug is typically taken for no more than 3 or 4 weeks at a time.
Why is this drug prescribed?
Zyprexa helps manage symptoms of schizophrenia, the manic phase of manic-depression, and other psychotic disorders. It is thought to work by opposing the action of serotonin and dopamine, two of the brain's major chemical messengers. The drug is available as Zyprexa tablets and Zyprexa Zydis, which dissolves rapidly with or without liquid.
Caution! Before starting to take this medicine, it is vital that you should consult your doctor! Do not use it on your own initiative, without medical advice.
Schizophrenia drug
Zyprexa notes:
Zyprexa (zyprexia) generic equivalent Olanzapine is an antipsychotic drug use to treat the symptoms of schizophrenia and bipolar disorder (manic depression) in adults and children who are at least 10 years old. Zyprexa is sometimes used together with another medication called fluoxetine (Prozac, Sarafem). Zyprexa is not for use in psychotic conditions related to dementia. Olanzapine may cause heart failure, sudden death or pneumonia in older adults with dementia-related conditions.
Zyprexa side effects includes fever, stiff muscles, sweating, fast or uneven heartbeats, jerky muscle movements, sudden numbness(especially on one side of the body), sudden headache, confusion, problems with vision, speech, increased thirst, frequent urination, excessive hunger, feeling light-headed, fainting, unusual thoughts(or behavior), hallucinations, thoughts about hurting yourself, nausea, stomach pain, low fever, loss of appetite, dark urine, clay-colored stools, jaundice, constipation, swelling in your hands/feet, back pain, weight gain, increased appetite, upset stomach, hives, swelling face/lips/tongue/throat.
Some of the drugs like carbamazepine (Tegretol), fluvoxamine (Luvox), medication to treat Parkinson's disease including levodopa (Sinemet, Larodopa, Atamet), selegiline (Eldepryl, Emsam), pramipexole (Mirapex), ropinirole (Requip) or medication to treat high blood pressure/heart condition can alter the olanzapine effects.
Ziprexa is the mexican name of the same drug. The recommended starting Zyprexa dose is 5 mg to 10 mg once daily. It can be taken with or without food. To take olanzapine orally disintegrating, place it in mouth. It will begin to dissolve right away. It may take up to 4 weeks of using this medicine before symptoms improve.
If a dose is missed, it is advised to consume it as soon as it is remembered. If it is near the time of the next dose, the missed one should be skip and the usual dosing schedule should be resume and strictly not to double the dose to catch up. Seek emergency medical attention if you think you have used too much of this medicine.
Avoid drinking alcohol, which can increase some of the side effects of Zyprexa. It is not known whether Zyprexa is harmful to an unborn baby. Before taking this medication, tell doctor if you are pregnant or plan to become pregnant during treatment. Olanzapine can pass into breast milk and may harm a nursing baby.
The tablet may contain phenylalanine.Talk to doctor before using this form of olanzapine if you have phenylketonuria (PKU). Store Zyprexa at room temperature away from moisture and heat.
Zyprexa news
The U.S. Food and Drug Administration (FDA) Psychopharmacologic Drugs Advisory Committee have voted in support that zyprexa which is an atypical antipsychotic is effective and considerably safe for the acute treatment of schizophrenia or manic/mixed episodes associated with bipolar I disorder in adolescents aged 13-17 years old. The panel supported the FDA and Lilly's position in approval of zyprexa for the two indications provided prescribers should consider other treatment options first for adolescent patients.
John Hayes(M.D., vice president of Lilly Research Laboratories) said that the committee of experts spent two days discussing the science of a difficult topic being debated in media, doctors' offices and living rooms across the country. He further added that today's committee vote is an important step toward providing help and hope to the many teens suffering from severe mental illness.
For the proposed schizophrenia indication, the panel voted 11-5 with two abstentions, that
has demonstrated zyprexa's effectiveness and voted 10-4 with four abstentions, that these data demonstrated acceptable safety. For the proposed indication for manic or mixed episodes associated with bipolar I disorder, the panel voted 17-0, with one abstention that zyprexa's effectiveness had been demonstrated, and voted 11-4 with three abstentions, that these data demonstrated acceptable safety.
The committee examined findings from two pivotal clinical trials of zyprexa in adolescents with schizophrenia or bipolar I disorder including a six-week double-blind, placebo-controlled trial to assess the efficiency and safety of zyprexa in 72 adolescents (aged 13-17 years old) with schizophrenia and a three-week randomized double-blind placebo-controlled trial to assess the efficacy and safety of zyprexa in 107 adolescents (aged 13-17 years) with acute manic or mixed episodes associated with bipolar I disorder.
Zyprexa story:
Zyprexa is an atypical antipsychotic that belongs to the thienobenzodiazepine class approved by the FDA for the treatment of schizophrenia and bipolar disorder It is intended for oral administration only. Zyprexa is structurally similar to clozapine but is classified as a thienobenzodiazepine. It has a higher affinity for 5-HT2 serotonin receptors than D2 dopamine receptors. Like most of the atypical antipsychotics zyprexa has lower affinity for histamine, cholinergic muscarinic and alpha adrenergic receptors. It also has weak affinity for benzodiazepine receptors which might be contributing to its sedating properties. The mode of action for zyprexa's antipsychotic activity is unknown, it may involve antagonism at serotonin receptors.
Zyprexa can increase the risk of developing hyperglycemia and diabetes both of which are factors in the metabolic syndrome. Of all the atypical antipsychotics, zyprexa is one of the most likely to induce weight gain based on various measures. There are some case reports available of zyprexa-induced diabetic ketoacidosis.
A clinical trial was conducted for the treatment of acquired neurogenic stuttering using zyprexa. Generally stuttering is most commonly treated with speech therapy and psychotherapy but number of antipsychotic agents have been investigated as possible treatments. In the case the medication was given to a 37 year old man who developed a post-concussive syndrome with psychosis and associated stuttering after his second exposure to a blast from an improvised explosive device. After treatment with zyprexa, his psychosis and stuttering showed significant improvement.
Zyprexa is quite effective at treating the multiple domains of schizophrenia with a low risk of extra-pyramidal side-effects. However its use gets restricted due to its metabolic side effects particularly obesity. Zyprexa have a high affinity for the H1 receptor and meta-analyses shows a strong correlation between risk of weight gain and H1 receptor affinity. In addition, zyprexa treatment decreases H1 receptor binding and mRNA expression in the rat hypothalamus. Also a complex role is emerging for the histamine H3 receptor in the control of hunger which is a pre-synaptic autoreceptor that inhibits the synthesis and release of histamine and a heteroreceptor that inhibits other neurotransmitters such as serotonin (5-HT), noradrenaline (NA) and acetylcholine (ACh), which are also implicated in the regulation of food intake. This indicates that the H3 receptor is in a prime position to regulate food intake, both through its control of histamine and its influence on other feeding pathways. A report proposed that mechanism for atypical antipsychotic-induced weight gain may be partly through the H3 receptor as a drug-induced decrease in H1 receptor activity may decrease histamine tone through the H3 autoreceptors, compounding the weight gain problem.
In a clinical trial undertaken for treating the symptoms of schizophrenia, zyprexa shows much superior results as compared to placebo. The patients were assessed using several test instruments including the Brief Psychiatric Rating Scale (BPRS), an 18-item inventory of symptoms traditionally used to evaluate the effects of drug treatment in psychosis. The BPRS score was extracted from the Positive and Negative Syndrome scale (PANSS) which is a 30-item rating instrument that evaluates each symptom item on a scale of 1 (absent) to 7 (extreme). The psychotic symptoms that were assessed includes conceptual disorganization, hallucinatory behavior, suspiciousness and unusual thought content. A second assessment Clinical Global Impression (CGI) was done to measure the overall severity of the illness. In addition, patients were evaluated on the PANSS and the Scale for Assessing Negative Symptoms (SANS). In a six-week, placebo-controlled trial involving 149 patients who received either placebo or a fixed dose of zyprexa at 1 and 10 mg/day. In this trial, zyprexa at 10 mg/day was superior to placebo on the PANSS total score, on BPRS total, the PANSS negative symptom sub-scale and on CGI severity.
In a six-week, placebo-controlled trial involving 253 patients who received placebo or one of three fixed dose ranges of Zyprexa (5 +/- 2.5 mg/day, 10 +/- 2.5 mg/day, 15 +/- 2.5 mg/day). The two highest zyprexa doses were superior to placebo on the BPRS total score and CGI severity score. The highest Zyprexa dose was statistically superior to placebo on the SANS.
References:
Definition of Olanzapine - National Cancer Institute
Moyer, Paula . "CAFE Study Shows Varying Benefits Among Atypical Antipsychotics". Medscape Medical News (WebMD). Retrieved 2007-12-03.
de Haan L, van Amelsvoort T, Rosien K, Linszen D (2004). "Weight loss after switching from conventional olanzapine tablets to orally disintegrating olanzapine tablets". Psychopharmacology (Berl) 175 (3): 389–90. doi:10.1007/s00213-004-1951-2. PMID 15322727
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Drug category:Schizophrenia, Psychosis
 Zyprexa
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