Zofran |
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Zofran (Ondansetron) is used for the prevention of nausea and vomiting caused by radiation therapy and chemotherapy for cancer, and, in some cases, to prevent these problems following surgery.
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| Dosage |
Packing |
Price |
Add to basket |
| 4 mg |
15 tab |
USD 97.00 |
 |
| 8 mg |
15 tab |
USD 175.00 |
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Zofran generic (generic - what is it?)
| Dosage |
Packing |
Price |
Add to basket |
| 4 mg |
100 tab |
USD 69.00 |
|
| 8 mg |
100 tab |
USD 89.00 |
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Zofran: Medications and Prescriptions
Generic name: Ondansetron
Product Brand Name: Zofran ®
Product Manufacturer: GlaxoSmithKline
Zofran description
Why is this drug prescribed?
Zofran is used for the prevention of nausea and vomiting caused by radiation therapy and chemotherapy for cancer, and, in some cases, to prevent these problems following surgery.
Most important fact about this drug
To ensure the maximum effect, it is important to take all doses of Zofran exactly as prescribed by your doctor.
How should you take this medication?
Your doctor will tell you how much drug to take and how often, depending on the type of therapy you will be having. Zofran is available in three forms: an oral solution, tablets that you swallow with water, and orally disintegrating tablets that can be swallowed with saliva alone (Zofran ODT). If you're taking the orally disintegrating tablets, don't remove them from the blister pack until it's time for a dose. Then peel off the foil backing with dry hands, gently remove the tablet, and immediately place it on your tongue. Do not attempt to push the tablets through the foil.
--If you miss a dose... Take the forgotten dose as soon as you remember.
Storage
Store Zofran at room temperature. Protect from light. Keep the drug in the carton it came in. Store oral solution bottles upright.
What side effects may occur?
Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Zofran.
· More common side effects may include:
Constipation, diarrhea, dizziness, fatigue, headache
· Less common side effects may include:
Anaphylaxis (severe allergic reaction), anxiety, fever, flushing, gynecological disorders, hiccups, hives, itching, rash, rolling eyes, urinary difficulties, wheezing
· When Zofran is used to prevent nausea and vomiting after surgery, the following side effects may occur:
Anxiety, difficulty breathing, difficulty urinating, dizziness, drowsiness, female reproductive disorders, fever, headache, itching, low blood pressure, shivers, slow heartbeat
Why should this drug not be prescribed?
If you are sensitive to or have ever had an allergic reaction to ondansetron hydrochloride, you should not take this medication. Make sure that your doctor is aware of any drug reactions that you have experienced.
Special warnings about this medication
If drugs similar to Zofran (for instance, Anzemet or Kytril) have given you a reaction, Zofran may cause one too. If you suffer from phenylketonuria (an excess of the amino acid phenylalanine) remember that Zofran contains this substance.
Possible food and drug interactions
No interactions with Zofran have been reported.
Special information if you are pregnant or breastfeeding
The effects of Zofran during pregnancy have not been adequately studied. If you are pregnant or plan to become pregnant, inform your doctor immediately. Zofran may appear in breast milk and could affect a nursing infant. If this medication is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment with this medication is finished.
Recommended dosage
Dosage is the same for both regular and orally disintegrating tablets. If you have poor liver function, you should take no more than 8 milligrams of Zofran per day.
PREVENTION OF NAUSEA AND VOMITING DUE TO CHEMOTHERAPY
Adults and Children 12 Years of Age and Older
The recommended dose of Zofran is one 8-milligram tablet or 2 teaspoonfuls of oral solution taken twice a day. The first dose should be taken 30 minutes before the start of treatment. The other dose should be taken 8 hours after the first dose. One 8-milligram tablet or 2 teaspoonfuls should be taken twice a day (every 12 hours) for 1 to 2 days after completing chemotherapy.
If the chemotherapy is especially likely to cause nausea and vomiting, the recommended dosage is one 24-milligram tablet taken 30 minutes before the treatment.
Children 4 through 11 Years of Age
The recommended dose of Zofran is one 4-milligram tablet or 1 teaspoonful of oral solution taken 3 times a day. The first dose should be taken 30 minutes before the start of chemotherapy. The other 2 doses should be taken 4 and 8 hours after the first dose. One 4-milligram tablet or 1 teaspoonful should be taken 3 times a day (every 8 hours) for 1 to 2 days after completing chemotherapy.
PREVENTION OF NAUSEA AND VOMITING DUE TO RADIATION THERAPY
Adults
The usual dosage is one 8-milligram tablet or 2 teaspoonfuls of oral solution taken 3 times a day. You will take the first dose 1 to 2 hours before therapy; the other intervals will depend on the type of radiation therapy you are receiving.
Children Zofran has not been used for this purpose in children.
PREVENTION OF NAUSEA AND VOMITING AFTER SURGERY
Adults The usual dose is two 8-milligram tablets or 4 teaspoonfuls of oral solution taken 1 hour before undergoing anesthesia.
Children Zofran has not been used for this purpose in children.
Overdosage
Any medication taken in excess can have serious consequences. If you suspect an overdose, seek medical attention immediately.
· Symptoms of Zofran overdose may include:
Low blood pressure and fainting, sudden blindness, severe constipation
Caution! Before starting to take this medicine, it is vital that you should consult your doctor! Do not use it on your own initiative, without medical advice.
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Zofran notes:
Zofran generic equivalent Ondansetron prevents nausea and vomiting caused by cancer chemotherapy or after surgery. It works by blocking the hormone (serotonin) that causes vomiting.Ondansetron reduces the activity of the vagus nerve, which activates the vomiting center in the medulla oblongata.
It has little effect on vomiting caused by motion sickness, and does not have any effect on dopamine receptors or muscarinic receptors.
This medication may also be used to treat alcoholism.
Zofran side effects includes diarrhoea, headache, lightheadedness or drowsiness (uncommon), blurred vision, slow heart rate, anxiety, agitation, shivering, chest pain and urinating less than usual or not at all.It may impair thinking or reactions. Be careful if you drive or do anything that requires you to be awake and alert.
In the unlikely event allergic reaction to this drug may occur. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, trouble breathing.It is recommended to consult doctor immediately if any of the side effects gets worsened.
Do not use this medication if you have liver disease or allergic to ondansetron hydrochloride, to similar medicines such as dolasetron (Anzemet), granisetron (Kytril), palonosetron(Aloxi) or a personal/family history of Long QT syndrome.
The recommended Zofran dosage is 8mg. It may be taken with or without food. It may also be taken with antacids. The first dose is usually taken 30 minutes before chemotherapy.
For maximum Zofran effect, it is necessary to take medication as prescribed by doctor. The Zofran orally disintegrating tablet can be taken with water/liquid or can be swallowed with saliva alone(Zofran odt). Allow it to dissolve in mouth without chewing.
Consult doctor regarding medical history, especially of stomach/intestinal problems, liver disease, any allergies. The effect of Zofran during pregnancy is not known, though consult doctor if you are pregnant before using this medication.Limit alcohol
intake, as it may intensify drug side effects. It is not known if this drug is excreted into breast milk.
Store Zofran at room temperature away from moisture and heat.
Zofran Cost ::
Dosage Packing Price
4 mg 15 tab USD 97.00
8 mg 15 tab USD 175.00
Zofran news:
The Food and Drug Administration in 2007 approved the first generic versions of zofran (Ondansetron) tablets, orally disintegrating tablets and oral solution which are indicated to prevent nausea and vomiting associated with surgery, radiotherapy and cancer chemotherapy. The approval is an important step in the agency's effort to increase the availability of lower-cost generic medications. In 2005, ondansetron was the 20th highest-selling brand-name drug in the United States Of America.
Gary J. Buehler, director, Office of Generic Drugs said that this approval will result in significant savings for the american public. He further added saying generic drugs are safe and effective alternatives to brand name drugs and undergo a thorough scientific and regulatory review.
The economic benefits of FDA's generic drug approval program will be significant because generic drug products which are used to fill over 50 percent of all prescriptions frequently cost a fraction of the price of the brand-name drugs. Such savings are likely to increase as more and more competitors will enter the market.
The office of Generic Drugs reviews and takes action on generic drug applications as expeditiously as possible. The same thorough and rigorously scientific review standards of safety, efficacy and quality are applied to generic drug applications as are applied to new drug applications. Consumers and health professionals can be assured that an approved generic drug is bioequivalent to a brand name drug and is its equal in dosage form, strength and performance characteristics.
Zofran story:
Zofran is a serotonin 5-HT3 receptor antagonist used mainly as an antiemetic to treat nausea and vomiting following chemotherapy. The recommended I.V. dosage of zofran for adults is a single 32-mg dose or three 0.15-mg/kg doses. A single 32-mg dose is infused over 15 minutes beginning 30 minutes before the start of emetogenic chemotherapy. The recommended infusion rate should not be exceeded beyond the recommended dosage.
The 5-HT3 receptor antagonists are the primary drugs used to treat and prevent chemotherapy-induced nausea and vomiting (CINV). As per the requirement they are given intravenously about 30 minutes before beginning therapy. It is also effective in controlling post-operative nausea and vomiting (PONV) and post-radiation nausea and vomiting. It is also a possible therapy for nausea and vomiting due to acute or chronic medical illness or acute gastroenteritis. This drug is highly effective in controlling PONV and CINV but its high cost had limited its use. It is also used off-label to treat hyperemesis gravidarum in pregnant women but there is no conclusive data available on its safety in pregnancy, especially during the first trimester.
Zofran is extensively metabolized in humans, with approximately 5% of a radiolabeled dose recovered as the parent compound from the urine. The primary metabolic pathway is hydroxylation on the indole ring followed by glucuronide or sulfate conjugation. Although some nonconjugated metabolites have pharmacologic activity, these are not found in plasma at concentrations likely to significantly contribute to the biological activity of zofran. In vitro metabolism studies have shown that zofran is a substrate for human hepatic cytochrome P-450 enzymes including CYP1A2, CYP2D6 and CYP3A4.
A 2006 double-blind, randomized controlled trial indicated that zofran can help in the treatment of schizophrenia subordinated by haloperidol. The study found that this combination improves negative schizophrenia symptoms upto a considerable level and people taking both drugs experienced fewer of the adverse effects commonly associated with haloperidol. Earlier a small open-label trial had found zofran to be useful in treating antipsychotic-induced tardive dyskinesia in people with schizophrenia and in the study patients also showed significant improvement in the disease's symptoms.
Researchers at the Stanford University School of Medicine have demonstrated that zofran might be useful and effective for treating withdrawal symptoms of opioid addictions. Unlike the existing treatments methadone and buprenorphine it is not an opioid and it doesn't require continued supervision like treatment with clonidine.
The study was undertaken using mice who were injected with increasing doses of morphine assayed with naloxone and then underwent haplotypic analysis to isolate a gene candidate. HTR3A which codes for the 5-HT3 receptor emerged as the primary candidate which suggested 5-HT3 antagonist zofran as a possible treatment. Then the researchers showed the efficacy in withdrawal symptom control in humans by an acute morphine administration model.
A study was carried out to investigate the effect of zofran in combination with dexamethasone in the prevention of higher incidence of postoperative nausea and vomiting(PONV) following strabismus repair in pediatric patients. Hundred healthy children of ASA class I and II aged 4-12 years who were scheduled for elective strabismus surgery were enrolled in this study. No premedications were given and anesthesia was induced by inhalational technique using sevoflurane, nitrous oxide and oxygen mixture. Fentanyl and atracurium were given and an endotracheal tube was inserted. Patients were randomly divided into four groups which received intravenously either placebo or a combination of zofran 50 microg/kg(-1) along with dexamethasone 0.5 mg/kg(-1) after induction of anesthesia and before start of surgery. All episodes of PONV during the first 24 hours after anesthesia were recorded. The incidence of postoperative nausea was 48%, 8%, 12% and 0% while the incidence of vomiting was 52%, 12%, 4% and 0% in placebo, zofran and dexamethasone which shows that prophylactic administration zofran combined with dexamethasone decreases the incidence of PONV following strabismus surgery in pediatrics.
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Drug category:Anti-cancer drugs
 Zofran
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