Tamoxifen |
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Tamoxifen is a medicine that blocks the effects of the estrogen hormone in the body. It is used to treat breast cancer in women or men. It may also be used to treat other kinds of cancer, as determined by your doctor. Tamoxifen also may be used to reduce the risk of developing breast cancer in women who have a high risk of developing breast cancer.
tamoxifen breast, tamoxifen weight, tamoxifen ovarian, tamoxifen weight gain, tamoxifen breast cancer, generic nolvadex, nolvadex buy, zitazonium.
| Dosage |
Packing |
Price |
Add to basket |
| 10 mg |
30 tab ($0.23 per tab) |
USD 7.00 |
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| 10 mg |
60 tab ($0.20 per tab) |
USD 12.00 |
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| 20 mg |
30 tab ($0.33 per tab) |
USD 10.00 |
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| 20 mg |
60 tab ($0.31 per tab) |
USD 19.00 |
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Tamoxifen: Medications and Prescriptions
Generic name: Tamoxifen
Product Brand Name: Nolvadex ®, Zitazonium ®
Tamoxifen description
Nolvadex, an anticancer drug, is given to treat breast cancer. It also has proved effective when cancer has spread to other parts of the body. Nolvadex is most effective in stopping the kind of breast cancer that thrives on estrogen. Other Names of Nolvadex: Dignatomoxi, Emblon, Fentamox, Istubol, Kessar, Mamofen, Noltam, Novofen, Oestrifen, Tamaxin, Tamifen, Tamoplex, Tamoxen, Valodex, Zitazonium
Nolvadex is also reduce the risk of invasive breast cancer following surgery and radiation therapy for ductal carcinoma in situ. The drug can also be used to reduce the odds of breast cancer in women at high risk of developing the disease. It does not completely eliminate your chances, but in a five-year study of over 1,500 high-risk women, it slashed the number of cases by 44 percent.
Most important fact about this drug:
Although Nolvadex (Tamoxifen) reduces the risk of breast cancer, it increases the possibility of developing endometrial (uterine) cancer. Women taking Nolvadex should have routine gynecological examinations and report any abnormal vaginal bleeding, changes in menstrual periods, change in vaginal discharge, or pelvic pain or pressure to the doctor immediately. Even after Nolvadex therapy has stopped, any abnormal vaginal bleeding should be reported at once.
How should you take this medication?
Take Nolvadex exactly as prescribed. Do not stop taking this medication without first consulting your doctor. It may be necessary to continue taking the drug for several years.
• If you miss a dose...
Do not try to make it up. Go back to your regular schedule with the next dose.
Storage
Nolvadex may be stored at room temperature.
What side effects may occur?
Side effects from Nolvadex are usually mild and rarely require the drug to be stopped. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Nolvadex.
• More common side effects may include:
Hot flashes, nausea, vomiting
• Less common side effects may include:
Bone pain, diarrhea, menstrual irregularities, skin rash, tumor pain, vaginal bleeding, vaginal discharge
• Rare side effects may include:
Blood clots, depression, distaste for food, dizziness, hair thinning or partial loss, headache, light-headedness, liver disorders, swelling of arms or legs, vaginal itching or dryness, visual problems
Why should this drug not be prescribed?
Do not take Nolvadex if you are sensitive to it or have ever had an allergic reaction to it.
If you are taking the blood-thinning drug Coumadin or have had problems with clots in your veins or your lungs, you should not take Nolvadex to reduce the risk of breast cancer, and when taking it to treat an actual case of the disease, you should use it with caution.
Special warnings about this medication:
In addition to increasing the risk of uterine cancer, Nolvadex also raises the odds of developing endometriosis (the spread of endometrial tissue outside the uterus), uterine fibroids, uterine polyps, and ovarian cysts.
Women who take Nolvadex also face a greater risk of stroke and of blood clots lodging in their lungs. The risk increases further when Nolvadex is combined with toxic cancer drugs. Nolvadex can also cause liver damage, and should be used with caution if you already have liver problems.
If you experience visual problems while taking Nolvadex, notify your doctor immediately.
In a few women Nolvadex may raise the level of cholesterol and other fats in the blood. Your doctor may periodically do blood tests to check your cholesterol and triglyceride levels.
Nolvadex may produce an abnormally high level of calcium in the blood. Symptoms include muscle pain and weakness, loss of appetite, and, if severe, kidney failure. If you experience any of these symptoms, notify your doctor as soon as possible.
If tests show that your blood contains too few white blood cells or platelets while you are taking Nolvadex, your doctor should monitor you with special care. These problems have sometimes been found in women taking Nolvadex; whether the drug caused the blood-cell abnormalities is uncertain.
Possible food and drug interactions:
If Nolvadex is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Nolvadex with the following:
Aminoglutethimide (Cytadren)
Blood-thinning drugs such as Coumadin
Bromocriptine (Parlodel)
Cancer drugs such as Cytoxan
Letrozole (Femara)
Phenobarbital
Rifampin (Rifadin)
Special information:
if you are pregnant or breastfeeding
It is important to avoid pregnancy while taking Nolvadex, because the drug could harm the unborn child. Since Nolvadex is an anti-estrogen drug, you will need to use a non-hormonal form of contraception, such as a condom and/or diaphragm, and not birth control pills. If you accidentally become pregnant while taking Nolvadex, or within 2 months after you have stopped taking it, discuss this with your doctor immediately.
Because Nolvadex might cause serious harm to a nursing infant, you should not breastfeed your baby while taking this drug. If this medication is essential to your health, your doctor may advise you to discontinue breastfeeding until your treatment is finished.
9. Recommended dosage:
ADULTS:
1) Breast Cancer Treatment
The daily dosage ranges from 20 to 40 milligrams. If you are taking more than 20 milligrams a day, your doctor will have you divide the total into 2 smaller doses taken in the morning and evening. Nolvadex comes in 10- and 20-milligram tablets.
2) Ductal Carcinoma in Situ
The recommended dose is 20 milligrams once daily for 5 years.
3) Breast Cancer Prevention
The recommended dose is 20 milligrams once a day for up to 5 years.
CHILDREN
Safety and efficacy in children have not been established.
Overdosage:
Any medication taken in excess can have serious consequences. If you suspect an overdose of Nolvadex, seek medical attention immediately.
• Symptoms of Nolvadex overdose may include:
Dizziness, overactive reflexes, tremor, unsteady gait
See also: Breast cancer
Tamoxifen notes:
Tamoxifen (generic name tamoxifen) is used to treat and prevent some types of breast cancer. It is used in women who are at high risk for breast cancer and in women with DCIS (after surgery and radiation). It blocks female hormone called estrogen there by preventing the growth of tumours that are activated by estrogen.
Hormones that cause breast cancer growth may also be blocked by ovarian function suppression using drugs, surgery or radiation to the ovaries. It is not yet known whether giving ovarian function suppression together with either tamoxifen citrate or exemestane is more effective than giving tamoxifen citrate alone in treating breast cancer.
Tamoxifen side effects includes sudden numbness, chest pain, shortness of breath, unusual vaginal bleeding or discharge, irregular menstrual periods, pale skin, new breast lumps, hot flashes, swelling in hands or feet, depressed mood, weakness, decreased sex drive or thinning hair. Weight gain can be a side effect of tamoxifen and this is sometimes due to water retention but at other times a consequence of a eating more either due to a increased appetite or mild nausea.
Generic Nolvadex is an orally active selective estrogen receptor modulator that is used in the treatment of breast cancer and is currently the world's largest selling drug for that purpose. It is also used to treat infertility in women with anovulatory disorders.
It is recommended to buy Nolvadex under doctor’s supervision and have blood levels checked regularly.
Other names of nolvadex includes zitazonium, Dignatomoxi, Emblon, Noltam, Novofen.
Store tamoxifen at room temperature away from moisture and heat.
Cancer news:
Acupuncture – effective substitute for breast cancer patients
According to a study at Henry Ford Hospital, acupuncture serves as an effective therapy for treatment of hot flashes in breast cancer patients. It also gives the added benefit by potentially increasing sex drive in women and improving their sense of well-being
Study lead author Eleanor Walker, M.D., division director of breast services in the Department of Radiation Oncology at Henry Ford Hospital said that acupuncture offers a safe, effective and durable treatment option for hot flashes. According to the statistics available one in every eight women suffers from breast cancer for which the conventional medical treatment involves chemotherapy and five years of hormone therapy. With such a long course of treatment, side effects of hormone therapy such as hot flashes and night sweats can become a major cause of decreased quality of life. In such cases, acupuncture is more helpful as it provides more benefit then its side effects.
Fifty patients were recruited for the study from oncology clinics at Henry Ford. Patients were randomly assigned to receive either acupuncture or conventional treatment for 12 weeks. The drug therapy group took 37.5 mg of venlafaxine orally each night for the first week and then 75mg for the remaining 11 weeks. The other group received acupuncture treatments twice per week for the first four weeks and then once a week for the remaining eight weeks. At the end of 12 weeks patients were asked to stop treatment and were followed for one year. The result showed that both groups initially experienced a 50 percent decline in hot flashes and depressive symptoms indicating that acupuncture is as effective as drug therapy.
Difference between the two groups were noticed after two weeks of treatment in which the acupuncture group continued to experience minimal hot flashes, while the drug therapy group had a significant increase in hot flashes.
Cancer news:
Calorie restriction and exercise prevents breast cancer in postmenopausal women – A research
Scientists at the University of Texas at Austin have identified pathways by which a reduced calorie diet and exercise can modify a postmenopausal woman's risk of breast cancer. The mTOR pathway is known to induce cancer. Caloric restriction and exercise have beneficial effects in disrupting pathways that lead to mTOR activation. Caloric restriction affects upstream pathway as compared to exercise and has more beneficial effect.
The increase in fat tissue alters adipokines which promote the risk of cancer. Out of three adipokines, two adipokines leptin and hepatocyte growth factor(HGF) increase the risk of breast cancer while adiponectin, a endogenous insulin sensitizer, decreases the risk of breast cancer.
In the experiment, 45 mice had their ovaries removed to simulate post menopausal state and then fed with high fat diet for 8 weeks. Then the mice were divided in four groups, a control group, one with caloric restriction of 30 percent, one permitted to eat at will and the other too permitted to eat at will but exercised for 45 minutes daily for five days a week. After the end of 8th week, the weight of calorie restricted mice was on average of 19.9 grams, that of control mice was 28.8 grams and of exercised mice was 26 grams. The tissues were put on histochemical analysis. The fat content of caloric restricted mice and the exercised mice were almost same and fat content was highest for that fed at will. The leptin levels were significantly less in caloric restricted mice and exercised mice as compared to control while adiponectin levels were highest in caloric restricted mice. The downstream proteins for mTOR activation were less in caloric restricted mice and exercised mice. The experiment shows the risks associated with obesity and the benefits of caloric restriction and exercise on prevention of cancer while caloric restriction has more pronounced anticancer effect.
Tamoxifen news:
Antidepressant can interfere with tamoxifen – A study
Breast cancer is the most commonly known cancer diagnosed in women and drug tamoxifen significantly helps in curing this disease. In the latest study, researchers have found that patients taking tamoxifen for the treatment of breast cancer may not get the full advantage of this medicine if taken along with some anti depressants. The researchers have stated that enzyme CYP2D6 is of prime importance to activate tamoxifen up to its optimum level. Antidepressants medicines like fluoxetine and paroxetine taken together with tamoxifen can restrict this important enzyme.
There were 2,430 women under taken for the study. Their respective health care record was studied by the researchers. About 30% of women were using antidepressant like fluoxetine, paroxetine and bupropion along with the treatment of tamoxifen. The result showed that women taking such anti depressant and tamoxifen were on higher risk of death and shows a drug interaction which is highly unwanted and is potentially life threatening. Dr. David Juurlink, one of the study’s author said that findings of study indicates the proper usage of anti depressants along with tamoxifen.
In another study 463 patients were used for the study. The researchers found that out of the total patients seven of them were receiving tamoxifen and sixteen were receiving an aromatase inhibitor along with strong CYP2D6 inhibitor which includes fluoxetine, paroxetine and bupropion. They also found that one patient on tamoxifen along with six other on aromatase inhibitor were receiving moderate CYPD6 inhibitor. Subjects on weak and moderate inhibitors were under gone test for metabolic activities before the start of tamoxifen treatment. All the seven patients receiving heavy dose of inhibitors were advised to alter the medication with equal amount of impact as that of tamoxifen.
The researchers stressed that patients should not stop taking tamoxifen but should understand that it is a situation where anti depressants inhibits the effect of the medicine.
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Drug category:Anti-cancer drugs
 Tamoxifen
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