Glucophage XR |
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Metformin, originally sold as Glucophage is an oral anti-diabetic drug in the biguanide class. It is the first-line drug of choice for the treatment of type 2 diabetes, particularly in overweight and obese people and those with normal kidney function. Metformin SR (slow release) or XR (extended release) was introduced in 2004, in 500 mg and 750 mg strengths, mainly to counteract the most common gastrointestinal side effects, as well as to increase patient compliance by reducing pill burden.
| Dosage |
Packing |
Price |
Add to basket |
| 500 mg |
60 tab |
USD 34.00 |
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| 500 mg |
120 tab |
USD 59.00 |
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| 750 mg |
60 tab |
USD 78.00 |
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| 750 mg |
120 tab |
USD 139.00 |
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Glucophage XR: Medications and Prescriptions
Generic name: metformin
Product Brand Name: Merckformin XR
Glucophage XR description
Each tablet contains the inactive ingredients sodium carboxymethyl cellulose, hydroxypropyl methylcel-lulose, microcrystalline cellulose, and magnesium stearate.
System Components and Performance GLUCOPHAGE XR tablets comprise a dual hydrophilic polymer matrix system. Metformin hydrochloride is combined with a drug release controlling polymer to form an "inner" phase, which is then incorporated as discrete particles into an "external" phase of a second polymer. After administration, fluid from the gastrointestinal (GI) tract enters the tablet, causing the polymers to hydrate and swell. Drug is released slowly from the dosage form by a process of diffusion through the gel matrix that is essen-tially independent of pH. The hydrated polymer system is not rigid and is expected to be broken up by normal peristalsis in the GI tract. The biologically inert components of the tablet may occasionally remain intact during GI transit and will be eliminated in the feces as a soft, hydrated mass.
ADVERSE REACTIONS
In a U. S. double-blind clinical study of GLUCOPHAGE in patients with type 2 diabetes, a total of 141 patients received GLUCOPHAGE therapy (up to 2550 mg per day) and 145 patients received place-bo. Adverse reactions reported in greater than 5% of the GLUCOPHAGE patients, and that were more common in GLUCOPHAGE-than placebo-treated patients, are listed in Table 11.
* Reactions that were more common in GLUCOPHAGE-than placebo-treated patients. Diarrhea led to discontinuation of study medication in 6% of patients treated with GLUCOPHAGE. Additionally, the following adverse reactions were reported in 1.0- 5.0% of GLUCOPHAGE patients and were more commonly reported with GLUCOPHAGE than placebo: abnormal stools, hypoglycemia, myalgia, lightheaded, dyspnea, nail disorder, rash, sweating increased, taste disor-der, chest discomfort, chills, flu syndrome, flushing, palpitation.
In worldwide clinical trials over 900 patients with type 2 diabetes have been treated with GLUCOPHAGE XR in placebo-and active-controlled studies. In placebo-controlled trials, 781 patients were administered GLUCOPHAGE XR and 195 patients received placebo. Adverse reac-tions reported in greater than 5% of the GLUCOPHAGE XR patients, and that were more common in GLUCOPHAGE XR-than placebo-treated patients.
* Reactions that were more common in GLUCOPHAGE XR-than placebo-treated patients Diarrhea led to discontinuation of study medication in 0.6% of patients treated with GLUCOPHAGE XR. Additionally, the following adverse reactions were reported in 1.0%- 5.0% of GLUCOPHAGE XR patients and were more commonly reported with GLUCOPHAGE XR than placebo: abdominal pain, constipation, distention abdomen, dyspepsia/ heartburn, flatulence, dizziness, headache, upper respiratory infection, taste disturbance.
GLUCOPHAGE XR are used to treat type 2 diabetes. This is also known as non-insulin-dependent diabetes mellitus. People with type 2 diabetes are not able to make enough insulin or respond normally to the insulin their bodies make. When this happens, sugar (glucose) builds up in the blood. This can lead to serious medical problems including kidney damage, ampu-tations, and blindness. Diabetes is also closely linked to heart disease. The main goal of treating diabetes is to lower your blood sugar to a normal level.
High blood sugar can be lowered by diet and exercise, by a number of medicines taken by mouth, and by insulin shots. Before you take GLUCOPHAGE or GLUCOPHAGE XR, try to control your dia-betes by exercise and weight loss. While you take your diabetes medicine, continue to exercise and follow the diet advised for your diabetes. No matter what your recommended diabetes manage-ment plan is, studies have shown that maintaining good blood sugar control can prevent or delay complications of diabetes, such as blindness.
GLUCOPHAGE and GLUCOPHAGE XR have the same active ingredient. However, GLUCOPHAGE XR works longer in your body. Both of these medicines help control your blood sugar in a number of ways. These include helping your body respond better to the insulin it makes naturally, decreas-ing the amount of sugar your liver makes, and decreasing the amount of sugar your intestines absorb. GLUCOPHAGE and GLUCOPHAGE XR do not cause your body to make more insulin. Because of this, when taken alone, they rarely cause hypoglycemia (low blood sugar), and usually do not cause weight gain. However, when they are taken with a sulfonylurea or with insulin, hypo-glycemia is more likely to occur, as is weight gain.
WARNING: A small number of people who have taken GLUCOPHAGE have developed a serious condition called lactic acidosis. Lactic acidosis is caused by a buildup of lactic acid in the blood. This happens more often in people with kidney problems. Most people with kid-ney problems should not take GLUCOPHAGE or GLUCOPHAGE XR.
Who should not take GLUCOPHAGE or GLUCOPHAGE XR? Some conditions increase your chance of getting lactic acidosis, or cause other problems if you take either of these medicines. Most of the conditions listed below can increase your chance of getting lactic acidosis.
Do not take GLUCOPHAGE or GLUCOPHAGE XR if you: ° have kidney problems
° have liver problems
° have heart failure that is treated with medicines, such as Lanoxin ® (digoxin) or Lasix ® (furosemide)
° drink a lot of alcohol. This means you binge drink for short periods or drink all the time
° are seriously dehydrated (have lost a lot of water from your body)
° are going to have an x-ray procedure with injection of dyes (contrast agents)
° are going to have surgery
° develop a serious condition, such as heart attack, severe infection, or a stroke
° are 80 years or older and you have NOT had your kidney function tested
Tell your doctor if you are pregnant or plan to become pregnant. GLUCOPHAGE and GLUCOPHAGE
XR may not be right for you. Talk with your doctor about your choices. You should also discuss your
choices with your doctor if you are nursing a child.
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Drug category:Antidiabetic agents
 Glucophage XR
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