Fosamax |
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Fosamax (generic name: alendronate) is prescribed for the prevention and treatment of osteoporosis, the brittle bone disease, in postmenopausal women. It is also used to increase bone mass in men with osteoporosis, and is prescribed for both men and women who have developed a form of osteoporosis sometimes caused by steroid medications such as prednisone. This drug can also be used to relieve Paget's disease of bone, a painful condition that weakens and deforms the bones.
Items: fosamax generic, fosamax dosage, fosamax drug, fosamax problems, fosomax, fossamax, didrocal, alendronate 70, osteonecrosis jaw.
| Dosage |
Packing |
Price |
Add to basket |
| 70 mg |
4 tab ($11.7 per tab) |
USD 47.00 |
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Fosamax generic (generic - what is it?)
| Dosage |
Packing |
Price |
Add to basket |
| 10 mg |
50 tab ($0.96 per tab) |
USD 48.00 |
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| 10 mg |
100 tab ($0.75 per tab) |
USD 75.00 |
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| 70 mg |
8 tab ($4.88 per tab) |
USD 39.00 |
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| 70 mg |
16 tab ($4.13 per tab) |
USD 66.00 |
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| 70 mg |
32 tab ($3.72 per tab) |
USD 119.00 |
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Fosamax: Medications and Prescriptions
Generic name: Alendronate
Product Brand Name: Fortimax
Fosamax description
Description:
Fosamax is in a class of medications used to strengthen bone. Bone is in a constant state of remodeling, whereby old bone is removed by cells called osteoclasts, and new bone is laid down by cells called osteoblasts. Fosamax inhibits bone removal by the osteoclasts. Fosamax was approved by the U.S. Food and Drug Administration for use in 1999.
Fosamax is Prescribed for:
To prevent and treat osteoporosis in postmenopausal women. Fosamax also treats glucocorticoid-induced osteoporosis in those receiving corticosteroids in a daily dosage equivalent to 7.5 mg or greater of prednisone and who have low bone mineral density. Also used to treat Paget's disease, a disorder characterized by rapid breakdown and reformation of bone, which can lead to fragility and malformation of bones.
Drug Mechanism:
Fosamax contains the active ingredient alendronate sodium, which is a type of medicine called a bisphosphonate. These agents are used in a variety of metabolic bone disorders.
The bone cells continuously deposit and remove calcium and phosphorous, stored in a protein network that makes up the structure of the bone.
Biphosphonates work by binding very tightly to bone, preventing the removal of calcium from the bone cells. This decreases breakdown and turnover of bone in the body and the increased calcium content leads to stronger bones.
In osteoporosis, bone turnover is increased, causing the bones to become weak and prone to breaking. This medicine slows done the process of bone breakdown, so keeping bones stronger and helping to prevent fractures. It is used to treat osteoporosis and prevent fractures in people with the disease, and also to prevent bone loss in people at risk of developing osteoporosis. Risk factors include a family history of osteoporosis, early menopause, thin body build, smoking and long-term corticosteroid treatment, eg with prednisolone.
Dosage Form:
For prevention of osteoporosis: 5 mg once a day. For treatment of osteoporosis: 10 mg once a day. For glucocorticoid-induced osteoporosis in men and women: 5 mg once a day; postmenopausal women not receiving estrogen should take 10 mg once a day. For Paget's disease: 40 mg once a day. The dose is taken in the morning. Swallow tablets whole; do not suck or chew them. For 30 minutes after taking this drug, do not lie down. Staying upright will help the alendronate reach your stomach faster, and will help prevent irritation in your throat.
Drug Interactions:
Calcium supplements, antacids and possibly other some medicines taken by mouth may interfere with the absorption of this medicine from the gut. For this reason you should wait at least 30 minutes after taking Fosamax, before taking any other medicines by mouth.
Pregnancy:
Fosamax is normally not used in premenopausal women. The drug should not be given to pregnant women because animal studies have shown adverse effects in the fetus.
Nursing Mothers:
The manufacturer states not to use Fosamax during breastfeeding as there is insufficient safety information available. Seek medical advice from your doctor.
Dietary and Alcohol Considerations:
Take Fosamax at least 30 minutes before your first food or beverage of the day, with a full glass of water. Some patients may be advised to take calcium or vitamin C supplements to aid in the formation of new bone tissue. Alcohol should be restricted in high-risk women because it is a risk factor for osteoporosis.
Possible Side Effects:
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with Fosamax. Because a side effect is stated here, it does not mean that all people using Fosamax will experience that or any side effect.
Headache
Rash
Excess gas in the stomach and intestines (flatulence)
Disturbances of the gut such as diarrhoea, constipation, nausea, vomiting or abdominal pain
Swelling of abdomen (abdominal distension)
Indigestion (dyspepsia)
Low blood calcium level (hypocalcaemia)
Pain in muscles or bones (musculoskeletal pain)
Flushing of the skin due to widening of the small blood vessels (erythema)
Dark colored, tarry stools, due to the presence of blood altered by the intestinal juices (melaena)
Inflammation of the food pipe (oesophagitis)
Difficulty or pain when swallowing (dysphagia)
Ulceration of the food pipe (oesophagus)
Acid regurgitation
Abnormal reaction of the skin to light, usually a rash photosensitivity)
Inflammation of the front parts of the eye (uveitis)
Storage:
Keep Fosamax in the container it came in, tightly closed, and out of reach of children. Fosamax should be stored at room temperature (77°F (25°C)) and away from excess heat and moisture (not in the bathroom). It is okay for brief periods in temperatures between 59-86°F (15-30°C). Throw away any medication that is outdated or no longer needed.
Package Size and Type:
Tablets: 70 mg.
Where can I get more information?
a) U.S. National Library of Medicine and National Institutes of Health
b) WebMD Corporation
Caution! Before starting to take this medicine, it is vital that you should consult your doctor! Do not use it on your own initiative, without medical advice.
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Fosamax notes:
Fosamax or Fosomax or Fossamax is widely used for the treatment of brittle bone disease called osteoporosis that affects most of the postmenopausal women. Fosamax generic name – alendronate that is also the main component of Fosamax helps in bone formation and prevents bone breakdown in the body thus reducing bone fractures. Fosamax drug is also prescribed to both men and women to cure a type of osteporosis induced by intake of corticosteroid medications like prednisone for longer periods. Fosamax is also effective in treating Paget’s disease of bone causing breakdown and malformation of bones.
Individuals may or may not face certain Fosamax problems or side effects due to regular usage of Fosamax. One is advised to seek immediate medical attention if one faces any of the side effects:
• Abdominal distension
• Stomach aches, nausea, diarrhoea, vomiting or constipation
• Headache
• Rash
• Indigestion
• Soreness of muscle, joints, or bones
• Low blood calcium level (hypocalcaemia)
• Irritation ulceration of the food pipe causing
. Difficulty in swallowing
• Swelling and pain in front parts of eye
• Passing dark coloured stools
• Irritation of skin due to exposure to light
• And others
Fosamax users also have the possibility of suffering from rare jaw disorder - osteonecrosis jaw also called “death of bone” in the jaw that involves swelling, pain and exposed bone.
You would be generally advised to swallow and not suck or chew Fosamax tablet in the morning with a full glass of water (about 6-8 ounces). Also one should remember not to lie down immediately and sit, stand or walk upright for at least 30 minutes. This would allow the medicine reach your stomach faster and prevent throat irritation. Normal Fosamax dosage includes –
• 5 mg daily for preventing osteoporosis
• 10 mg daily for treating osteoporosis.
• 5 mg daily for glucocorticoid-induced osteoporosis
• 10 mg daily for shortage of estrogen in postmenopausal women
• 40 mg daily for treating Paget's disease
Alternatively Alendronate 70 mg can be taken once weekly for prevention and treatment of all types of osteoporosis. Please note Didrocal and Fosamax are often confused as the same drug by patients. However, you should consult your doctor and take his advice before you start taking Fosamax.
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Balance protein intake increases life span – A research
The new research done by Wellcome Trust and Research have suggested that correct balance of proteins in diet of ageing people is more beneficial then reducing calories. Research done on mice, rats and the rhesus monkey have shown longer life when kept on food restriction while maintaining sufficient quantities of vitamins, minerals and other important nutrients. This suggests that dietary restriction can be helpful in humans also.
To analyze the health benefits of dietary restriction, researchers at the Institute of Healthy Ageing University College London conducted a study on female fruit flies. The fruit flies were given a diet of yeast, sugar and water with varying amounts of vitamins, lipids and amino acids. From this the researchers found that varying the amount of amino acids in the mixture affected lifespan and fertility of flies. The further analyses showed that levels of a particular amino acid known as methionine were crucial in maximising lifespan without decreasing fertility.
Dr Matthew Piper, one of the study authors said that by carefully manipulating the balance of amino acids in the diet it is possible to maximise both lifespan and fertility which arises the possibility of extending lifespan without wholesale dietary restrictions.
Anti-Aging News:
Supplement that offsets aging – says Scientists.
According to the latest development, scientists at McMaster University have claimed to produce dietary supplement which helps to offset declining physical activity known to be the key symptom of aging. The supplement will prove to be helpful in extending physical function and improving quality of life. Decline in physical activity is one of the most reliable expressions of aging and obesity.
Scientists combined number of dietary supplements into one compound and administered them on certain group of mice. The result showed that mice on such dietary supplement were able to maintain youth levels as the supplement increases the activity of mitochondria which energy and reduces the amount of free radicals which are the basic cause of aging.
In the group of mice that does not receive supplement, scientists observe 50 percent decline in daily physical activities, in activity of mitochondria and loss in brain chemicals associated with locomotion. The supplement consists of thiamin, vitamins C, D, and E, folic acid, garlic, ginger root, potassium, cod liver oil, ginkgo biloba, ginseng, beta-carotene, green tea extract and magnesium. Many of these substances are related to anti aging activities because of their anti oxidant properties.
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Drug category:Bone resorption inhibitor
Fosamax
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