Parkinsonism is a group of neurological disorders characterized by hypokinesia, tremor and muscular rigidity. Its most common form (Parkinson’s disease) is paralysis agitans, usually occurring in late life. There is degeneration within the nuclear masses of the extrapyramidal system and a characteristic reduction in dopamine levels. It is a slowly progressive disease characterized by mask like facies, a tremor of resting muscles, a slowing of voluntary movements, a festinating gait and peculiar posture. There may be excessive sweating and heat sensations. Although the disease cannot be cured, there are various agents which can relieve its symptoms, the most common of which are levodopa and anticholinergic drugs.
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Adamantan Amantadine is a synthetic (man-made) anti-viral drug that can inhibit the replication of viruses in cells. To prevent a viral infection, the drug should be present before exposure to the virus. Clearly, this is not practical for most viral infections. It was initially used to prevent influenza A during flu season, and, if given within 24 to 48 hours of the onset of flu symptoms, to decrease the severity of the flu.
Later amantadine was found to cause improvement in the symptoms of Parkinson's disease. Amantadine's mechanism of action in Parkinson's disease is not fully understood. Its effects may be related to its ability to augment (amplify) the effects of dopamine, a neurotransmitter in the brain, that is reduced in Parkinson's disease. Amantadine is less effective than levodopa in Parkinson's disease but can offer additional benefit when taken with levodopa.
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Bromocriptine Bromocriptine (also known as Parlodel), an ergoline derivative, is a dopamine agonist that is used in the treatment of
...pituitary tumors,
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a versatile drug with life-extending properties
Deprenyl (deprenyl selegiline), first intended as an antidepressant, is commonly used in the treatment of Parkinson’s disease, and also as a life-extension drug. It is also being applied in the treatment of a range of other conditions. It enhances and protects mental function, and helps in retaining libido and a positive mood. It is very safe in use. Thus, particularly in its life-extension role, not just the length of life is increased, but also the quality of life.
Deprenyl is a modification of PEA (phenyl ethylamine), an endogenous member of the family to which the neurotransmitters noradrenalin and dopamine belong. The drug is available as L-deprenyl, also known as Selegiline. The active ingredient in the tablet form is deprenyl hydrochloride, i.e. it has a bond between deprenyl and an inorganic component. It is also available as deprenyl citrate – the most potent form – which is instead composed of deprenyl bonded with an organic component.
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Eldepryl Selegiline (known as Jumex in Europe) protects against aging of the brain, enhances mental function. A powerful remedy against Parkinson's disease, Selegiline is effective also as an antidepressant and as a protector against Alzheimer's disease. Professor Knoll, who developed Selegiline is convinced of its anti-aging effect and recommends for this a dose 5 mg per week (in two doses of 2.5 mg each).
Exelon Exelon is used to treat mild to moderate dementia caused by Alzheimer's or Parkinson's disease. Exelon improves the function of nerve cells in the brain. It works by preventing the breakdown of a chemical called acetylcholine (ah see til KO leen). People with dementia usually have lower levels of this chemical, which is important for the processes of memory, thinking, and reasoning.
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Jumex Jumex (Selegiline), also known as Deprenyl, Eldepryl works by helping to conserve the amount of dopamine available by preventing the dopamine from being destroyed. While controversial, there is some evidence that this drug may slow the progression of Parkinson's disease, particularly early in the course of the disease.
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Madopar MADOPAR contains two active ingredients called levodopa and benserazide. MADOPAR belongs to a group of medicines called antiparkinsonian agents.
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Mirapexin Mirapex eases the symptoms of Parkinson's disease - a progressive disorder marked by muscle rigidity, weakness, shaking, tremor, and eventually difficulty with walking and talking. Parkinson's disease results from a shortage of the chemical messenger dopamine in certain areas of the brain. Mirapex is believed to work by boosting the action of whatever dopamine is available. The drug can be used with other Parkinson's medications such as Eldepryl, Sinemet, and Larodopa.
Selegilin Selegiline (known as Jumex in Europe) protects against aging of the brain, enhances mental function. A powerful remedy against Parkinson's disease, Selegiline is effective also as an antidepressant and as a protector against Alzheimer's disease. Professor Knoll, who developed Selegiline is convinced of its anti-aging effect and recommends for this a dose 5 mg per week (in two doses of 2.5 mg each).
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Sinemet Sinemet CR is a controlled-release tablet that may be given to help relieve the muscle stiffness, tremor, and weakness caused by Parkinson's disease. It may also be given to relieve Parkinson-like symptoms caused by encephalitis (brain fever), carbon monoxide poisoning, or manganese poisoning.
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