Aminoguanidine |
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Aminoguanidine is a medicine capable to slow down the aging processes. It is commonly considered that age-related changes in the body are caused by so called cross-linking (or glycosylation) of protein. Aminoguanidine is able to protect body-making-up proteins such as skin (collagen and elastin), eye lens, nerve and kidney proteins from linking by mixing itself up with substances that cause links and thus stops the aging of the body among which are senile cataracts, thickening of the arteries, some cancers, age-related toughening and yellowing of the skin and damage to the immune system. The results of such Aminoguanidine effect mean that it may be able to protect from or at least slow down the progression of those age-related conditions. It is also test-proven that Aminoguanidine has the capability of reducing the ability of very low density lipoprotein so called “bad cholesterol” to stick to blood vessel walls as the result blood platelets are less likely to coagulate and form dangerous atherosclerotic plaques. The medicine also shows the ability to prevent age-related heart enlargement and irregular glucose metabolism which causes diabetes to develop with age.
| Dosage |
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| 75 mg |
100 tab |
USD 39.00 |
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Aminoguanidine: Medications and Prescriptions
Generic name: Aminoguanidine
Product Brand Name: Aminoguanidine, Pimagidine
Aminoguanidine description
Description:
Aminoguanidine (pronounced a-mean-o-gwan-I-din) is capable of preventing advanced protein glycation, as well as inhibiting the activity of enzymes with carbonyl groups as cofactors, such as nitric oxide synthase and semicarbazide-sensitive amine oxidize. The hydrazide moiety of Aminoguanidine can also interact with different endogenous carbonyl metabolites and potentially harmful endogenous aldehydes. Aldehydes can be generated via different pathways, such as lipid peroxidase, oxidative deamination, and carbohydrate metabolism. Formaldehyde and methylglyoxal are produced via semicarbazide-sensitive amine oxidase — catalyzed deamination of methylamine and aminoacetone, respectively. An increase in semicarbazide-sensitive amine oxidase — mediated deamination is known to be associated with various vascular disorders, such as diabetic complications. The present study demonstrates that Aminoguanidine is not only capable of rapidly interacting with aldehydes in vitro, but also scavenging aldehydes in vivo. The Aminoguanidine -formaldehyde adducts were traced and their structures elucidated by HPLC-MS. Aminoguanidine has also been shown to block formaldehyde-induced beta-amyloid aggregation. Thus, Aminoguanidine can be an aldehyde scavenger in addition to blocking advanced glycation and inhibition of semicarbazide-sensitive amine oxidase and nitric oxide synthase activity. Such reactions may contribute to its pharmacological effects in the treatment of vascular disorders associated with diabetic complications and other disorders as well as complex aging of the human body.
Before Using:
Before starting taking Aminoguanidine consult your physician. It can inhibit the uptake of vitamin B6, so a B6 supplement is recommended while using Aminoguanidine. Aminoguanidine may be synergistic with Acarbose and Metformin. This product and its statements have not been evaluated by the FDA. This product is not intended to treat, cure or prevent any disease.
Dosage:
An effective anti-aging dosage of Aminoguanidine is from 150mg up to 300mg per day (75mg two, three of four times a day), taken with food. Diabetics may require increased dosages in the range of 300-600mg daily or even higher. Aminoguanidine has a half life of only 4-hours, so it is better to split the daily dose in equal doses during the day for better administration.
Side Effects:
The trials proved Aminoguanidine to have very low toxicity level and appear safe-to-use against average dosages. Side effects in human trials have been limited to nausea and headache and were caused by personal intolerability to the drug ingredients. Though, note that Aminoguanidine use is probably best undertaken under the supervision of a physician.
Anti-aging news:
Adolescents weight control strategies identified – Says researchers
In a study published in Journal of the American Dietetic Association researchers have claimed to find the weight control strategy for adolescents, which is a major public health problem that impacts one out of every three children resulting in 4-5 million overweight youth in the United States. The researchers said that from the statistics available it is clearly seen that weight control strategies for adolescents is necessary.
130 adolescents were taken into participation for this study, out of them 62 were successful in losing weight and 68 were not. The adolescents were interrogated and from the data achieved, the authors evaluated weight control strategies, sedentary behaviors, dietary intake, physical activity, weighing frequency and current weight status. The participants were distributed in four different groups, the first was Healthy Weight Control Behaviors group which includes less calories food, more exercise, eating less high fat and junk food, drinking less soda, drinking more water and eating more fruits. The second category was Unhealthy Weight Control Behaviors which includes laxatives, vomiting, diuretics, smoking and fasting, the third category was Extreme Dietary Changes included use of liquid diet supplements, the Atkins diet, a structured diet, fasting and increased protein consumption and the fourth category Structured Behaviors included eating certain amount of calories, counting calories, recording food intake and working with a professional
The successful adolescents were reported from the first group. A higher percentage of adolescents who lost weight reported using 6 or more Healthy Weight Control Behaviors compared to those who did not lose weight. Less number of adolescents who lost weight reported using any of the Structured Behavior strategies assessed. Kerri Boutelle, PhD and co-author of this study stated that these findings provide a glimpse of optimism that adolescents can lose a significant amount of weight and maintain this weight loss and that there are no magical solutions but by eating more fruits and vegetables, eating less fat and decreasing sedentary time can help considerably to achieve the goal.
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Drug category:Geroprotector
 Aminoguanidine
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